Autistic people have additional synapses and more branches of neurons. 5 Schizophrenic patients have lower brain volume in cortical regions due to reduced number of neuroglia. Identification of deep brain structures such as basal ganglia and their histological evaluation is also imperative for deep brain surgeries, treatment of tremor, and precise localization of nuclei in non-motor disease such as obsessive compulsive disorder etc. This area has been extensively studied for interaction of antipsychotic drugs and drug abuse due to its conundrum with amygdale. This area has island of small sized neurons with dopaminergic 3 receptors. 3 One of indigenous part of fundus striati is nucleus accumbens. It comprises of small and large sized neurons and splintering fibre bundles. The island of striatum caudal to anterior limb of internal capsule which is a connecting bridge between caudate nucleus and globus pallidus is termed as Fundus striati. 2 Caudate nucleus and Globus pallidus of Lentiform nucleus together are termed as Corpus striatum. The number, density, volume and morphology of neurons and neuroglia correlate with changes with brain function. The cellular composition of human nervous tissue comprises of three basic cell types: neurons, neuroglia and endothelial cells. Keywords: fundus striati, cell profiler, image analysis IntroductionĬonstant changing patterns of activity of billions of neurons have been extensively studied by thousands of scientists and neurologists as a matter of scientific rigor and most importantly for updating disease prevention and control measures. Cell profiler is cost effective software which is beneficial to identify and measure neurons of fundus striati. Results of the present study can be extrapolated to correlate with pathological conditions associated with emotional and behavioral disorders involving fundus striati. Mean Intensity units of neurons of fundus striati as measured by intensity module of Cell profiler was 17.916 pixel units. Using specific modules, neurons and branching points of their neurites in images of fundus striati were measured in pixel units. Neuronal nuclei were identified as primary objects and cytoplasm was identified by the software as secondary objects. Freely downloadable Cell Profiler software was installed, specific pipeline for neuronal assay was drawn, and modules were used to analyze images. A qualitative cross sectional study was done using eighty one images of histological sections of hematoxylin and eosin stained 8µ thick tissue sections of fundus striati. The present study was undertaken to study and analyze images of fundus striati using cell profiler as an automated image analysis technique. A versatile technique to measure neurons of fundus striati is the use of Cell profiler software. One such part of human brain which has been explored in recent years is fundus striati, a part of basal ganglia bridging caudate nucleus and putamen. It does not store any personal data.Analysis of volumetric and morphological neuronal data has been of keen interest to neurologists and neuroscientists because of its implications in pathological conditions such as schizophrenia, autism, obsessive compulsive disorder etc. The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. The cookie is used to store the user consent for the cookies in the category "Performance". This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Other. The cookies is used to store the user consent for the cookies in the category "Necessary". The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional". The cookie is used to store the user consent for the cookies in the category "Analytics". These cookies ensure basic functionalities and security features of the website, anonymously. Necessary cookies are absolutely essential for the website to function properly.
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